The Valenzano Lab



Willemsen D, Cui R, Reichard M, Valenzano DR (2020). Intra-species differences in population size shape life history and genome evolution. eLife 2020;9:e55794 DOI: 10.7554/eLife.55794.

Bradshaw WJ, Poeschla M, Placzek A, Valenzano DR (2020). Antibody repertoire sequencing reveals systemic and mucosal immunosenescence in the short-lived turquoise killifish. bioRxiv 2020.08.21.261248; doi:

Popkes M, Valenzano DR (2020). Microbiota–host interactions shape ageing dynamics. Phil. Trans. R. Soc. B 375: 20190596.

Cui R, Tyers AM, Malubhoy ZJ, Wisotsky S, Valdesalici S, Henriette E, Kosakovsky Pond SL, Valenzano DR (2020). Genomics of a killifish from the Seychelles islands supports transoceanic island colonization and reveals relaxed selection of developmental genes. bioRxiv,

Cui R, Willemsen D, Valenzano DR (2020). Nothobranchius furzeri (African Turquoise Killifish). Trends In Genetics,

Bradshaw WJ, Valenzano DR (2020). Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes. Proceedings of the Royal Society B, 287(1927)

Poeschla M, Valenzano DR (2020). The turquoise killifish: a genetically tractable model for the study of aging. Journal of Experimental Biology, 223:jeb.209296, doi: 10.1242/jeb.209296.

Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A (2019). Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology. EvoDevo, 10(1), 1-22,

Aleman F.D.D., and Valenzano DR (2019). Microbiome evolution during host aging. PLoS Pathogens 15, e1007727.

Metge F, Kim Y, Boucas J, Dieterich C, Valenzano DR (2019). Circular RNAs in the ageing African turquoise killifish. bioRxiv,

Cui R, Medeiros T, Willemsen D, Iasi LNM, Collier GE, Graef M, Reichard M, Valenzano DR (2019). Relaxed Selection Limits Lifespan by Increasing Mutation Load. Cell, Jul 11;178:1-15 (cover article).

Bradshaw WJ, Šajina A, Valenzano DR (2019). AEGIS: An In Silico Tool to model Genome Evolution in Age-Structured Populations. bioRxiv,

Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Emilse Vargas N, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L (2019). Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart . Embo Reports (2019) e47407.

Keesey IW, Grabe V, Gruber L, Koerte S, Obiero GF, Bolton G, Khallaf MA, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett BA, Knaden M, Hansson BS (2019). Inverse resource allocation between vision and olfaction across the genus Drosophila. Nature Communications. (2019)10:1162.

Valenzano DR (2018). Host-microbiota interactions during ageing. Old Herborn University Seminar Monograph 32: Ageing and the Microbiome. Old Herborn University Foundation, Herborn, Germany: 33-41.

Seidel J, Valenzano DR (2018). The role of the gut microbiome during host ageing. F1000Research 2018, 7(F1000 Faculty Rev):1086. doi: 10.12688/f1000research.15121.1.

Muck J, Kean S, Valenzano DR (2018). The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on ageing. In "Conn's Handbook of Models of Human Aging, 2nd Ed (May 2018). ISBN: 978-0-12-811353-0.

Dodzian J, Kean S, Seidel J, Valenzano DR (2018). A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri). J. Vis. Exp. (134), e57073, doi:10.3791/57073.

Smith P, Willemsen D, Popkes M, Metge F, Gandiwa E, Reichard M, Valenzano DR (2017). Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish. Elife. Aug 22;6. doi: 10.775/eLife.27014.

Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V (2017). Non-canonical aging model systems and why we need them. EMBO J. DOI: 10.15252/embj.201796837.

Harel I, Valenzano DR, Brunet A (2016). Efficient genome engineering in the short-lived African turquoise killifish. Nature Protocols. Oct; 11(10):2010-2028.

Kim Y, Nam HG, Valenzano DR (2016). The short-lived African Turquoise Killifish: an Emerging Model for Ageing. DMM, Feb 3;9(2):115-129 (cover article).

Šajina A, Valenzano DR (2016). An In Silico Model to Simulate the Evolution of Biological Aging.
[bioRxiv] [arXiv]

Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clement-Ziza M, Willemsen D, Cui R, Harel I, Machado B, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A (2015). The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan. Cell, Dec 3;162(6):1539-1554.

Reichard M, Cellerino A, Valenzano DR (2015). Turquoise Killifish. Current Biology. Aug;25(17): R741-2.

Cellerino A, Valenzano DR, Reichard M (2015). From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology. Biological Reviews. DOI: 10.1111/brv.12183.

Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A (2015). A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell. Feb 26;160(5):1013-26.

Publications before 2013 (selected)

Valenzano DR, Sharp S, Brunet A (2011). Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging. G3 (Bethesda). Dec;1(7):531-8.

Valenzano DR, Kirschner J, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, Brunet A (2009). Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics. Dec;183(4):1385-95.

Terzibasi E, Valenzano DR, Benedetti M, Roncaglia P, Cattaneo A, Domenici L, Cellerino A (2008). Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS One. 3(12):e3866.

Terzibasi E, Valenzano DR, Cellerino A (2007). The short-lived fish Nothobranchius furzeri as a new model system for aging studies. Exp Gerontol. Jan-Feb;42(1-2):81-9.

Valenzano DR, Terzibasi E, Cattaneo A, Domenici L, Cellerino A (2006). Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri. Aging Cell. Jun;5(3):275-8.

Valenzano DR, Cellerino A (2006). Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle. May;5(10):1027-32.

Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006). Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. Feb 7;16(3):296-300.

Genade T, Benedetti M, Terzibasi E, Roncaglia P, Valenzano DR, Cattaneo A, Cellerino A (2005). Annual fishes of the genus Nothobranchius as a model system for aging research. Aging Cell. Oct;4(5):223-33.

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